COMMENTS

  1. NIA-Funded Active Alzheimer's and Related Dementias Clinical Trials and

    NIA is currently supporting over 500 active clinical trials on Alzheimer's disease and dementia in many areas of research. See the comprehensive list. ... Rochester Roybal Center for Social Ties and Aging Research: Study of a Behavioral Intervention for Older Advanced Cancer Patients and Their Caregivers (Pilot)

  2. Clinical Trials for Alzheimer's & Dementia

    Clinical trials and research studies for Alzheimer's disease or other dementias - use Alzheimer's Association TrialMatch, a free online matching tool. Get information and resources for Alzheimer's and other dementias from the Alzheimer's Association. Call our 24 hours, seven days a week helpline at 800.272.3900. menu. About;

  3. Effects of intensive lifestyle changes on the progression of mild

    This study was registered retrospectively with clinicaltrials.gov on October 8, 2020 (NCT04606420, ID: 20172897). ... 16 Mass General Brigham Alzheimer Disease Research Center, Boston, MA, USA. 17 Elizabeth Blackburn Lab, UCSF, San Francisco, CA, USA.

  4. A Review of the Recent Advances in Alzheimer's Disease Research and the

    1. Introduction. Alzheimer's disease (AD) is a polygenic and multifactorial disease characterized by the deposition of amyloid-β (Aβ) fibrils in the brain, leading to the formation of plaques and neurofibrillary tangles (NFTs), and ultimately resulting in dendritic dysfunction, neuronal cell death, memory loss, behavioral changes, and organ shutdown [1,2,3,4,5].

  5. Researchers call for a major rethink of how Alzheimer's ...

    In studies of potential disease-modifying drugs for Alzheimer's disease, there has always been a tension between being able to produce a treatment effect and being able to measure it, says ...

  6. Alzheimer's disease

    A new study has identified prematurely senescent microglia in the vicinity of amyloid-β plaques in the brains of individuals with Alzheimer disease. Heather Wood Research Highlights 04 Jun 2024 ...

  7. Alzheimer's Disease Clinical Trials

    Exercise in Asymptomatic Pre-Alzheimer's Disease Pilot Study Jacksonville, FL 5.4 million Americans have Alzheimer's disease (AD) costing $185 billion annually, while 15 million caregivers look after these individuals. AD is the sixth leading cause of death, but the only one in the top 10 causes that cannot be prevented.

  8. Progress with Treatments for Alzheimer's Disease

    The inexorable progression of Alzheimer's disease exerts a huge toll on patients, families, and society, costing approximately $1 trillion annually, an amount that is likely to increase with the ...

  9. Emerging diagnostics and therapeutics for Alzheimer disease

    Abstract. Alzheimer disease (AD) is the most common contributor to dementia in the world, but strategies that slow or prevent its clinical progression have largely remained elusive, until recently ...

  10. Alzheimer's Disease Research Center

    Clinical trials are research studies that involve volunteer participants. These studies help physician-scientists better understand, diagnose, treat, and prevent diseases and conditions. Mayo Clinic's clinical trials related to dementia include studies of Alzheimer's disease, Lewy body dementia, frontotemporal degeneration, aging biomarkers and ...

  11. Current and Future Treatments in Alzheimer Disease: An Update

    Introduction. Alzheimer disease (AD) is one of the greatest medical care challenges of our century and is the main cause of dementia. In total, 40 million people are estimated to suffer from dementia throughout the world, and this number is supposed to become twice as much every 20 years, until approximately 2050. 1 Because dementia occurs mostly in people older than 60 years, the growing ...

  12. Comprehensive Review on Alzheimer's Disease: Causes and Treatment

    1. Introduction. Alzheimer's disease (AD) (named after the German psychiatric Alois Alzheimer) is the most common type of dementia and can be defined as a slowly progressive neurodegenerative disease characterized by neuritic plaques and neurofibrillary tangles (Figure 1) as a result of amyloid-beta peptide's (Aβ) accumulation in the most affected area of the brain, the medial temporal ...

  13. Large-scale study of brain proteins uncovers new clues to Alzheimer's

    The research team — located at Emory University School of Medicine, part of the Accelerating Medicines Partnership® Program for Alzheimer's Disease (AMP®-AD) Consortium — used advanced automated techniques to compare the levels of both proteins and RNA molecules in more than 1,000 brain tissue samples. The samples came from the ...

  14. AHEAD Alzheimer's Disease Clinical Trial

    The AHEAD Study is testing an investigational treatment aimed at delaying memory loss before noticeable signs of Alzheimer's disease begin. We are looking for people ages 55-80 who do not have noticeable symptoms of Alzheimer's disease, but who are interested in participating in clinical trials aiming to help prevent potential future memory ...

  15. Welcome

    Welcome to the Johns Hopkins Alzheimer's Disease Research Center. Follow our links to learn more about Alzheimer's disease, the Center, our research and our team members. Researchers associated with the Center are focused on understanding the earliest stages of Alzheimer's disease and related disorders, and on improving care of patients in the symptomatic phases of disease.

  16. Alzheimer's and Dementia Research

    Alzheimer's disease is one of the most devastating brain diseases characterized by progressive cognitive impairments, including memory loss and behavioral change. Hallmark neuropathologies include the extracellular deposition of β-amyloid (Aβ) in senile plaques and the intracellular aggregation of tau protein in the form of neurofibrillary ...

  17. New insights into the genetic etiology of Alzheimer's disease and

    Meta-analysis of genome-wide association studies on Alzheimer's disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of ...

  18. Participating in Alzheimer's Disease and Related Dementias Research

    Most Alzheimer's clinical trials require that each research participant enroll with a study partner — someone who knows the participant well, usually a family member or close friend. The study partner goes with the participant to research appointments and can provide insights about how their memory, thinking, and behavior changes over time.

  19. Alzheimer's study finds diet, lifestyle changes yield improvements

    The study's 51 subjects, whose average age was 73.5, were in the initial stages of Alzheimer's disease. and all had been diagnosed with mild cognitive impairment or early dementia. Twenty-six were randomly assigned to the intervention group and 25 to the control group.

  20. Alzheimer's disease: 120 years of research and progress

    THE FIRST STUDY ON ALZHEIMER'S DISEASE AND THE FIRST PATIENT DIAGNOSED. In 1901, Alois Alzheimer became interested in a patient at Frankfurt asylum named Auguste Deter (Figure 2), a 51-year-old female with unique symptomatology compared to normal dementia cases.She presented progressive confusion, sleep disorders, and, most importantly, memory loss [].

  21. Groundbreaking study reveals what Alzheimer's disease looks like inside

    The implications of this research extend far beyond Alzheimer's research. The techniques developed here could be applied to study a wide range of brain diseases, offering new perspectives on conditions that have long puzzled medical science. As the world population ages, understanding and treating dementia becomes increasingly crucial.

  22. In new criteria for Alzheimer's, some see much-needed progress while

    In an 18-month study of people who were in the early stages of Alzheimer's disease, the antibody lecanemab - which the US Food and Drug Administration approved in 2023 - slowed the rate of ...

  23. Alzheimer's & Dementia Research

    Alzheimer's and dementia research - find the latest information on research funding, grants, clinical trials and global research news. Get information and resources for Alzheimer's and other dementias from the Alzheimer's Association.

  24. Can we predict how fast cognitive decline will occur with early

    A new study looks at predicting how quickly people with early Alzheimer's disease will experience cognitive decline. The study is published in the July 10, 2024, online issue of Neurology ®, the ...

  25. Sex and gender differences in cognitive resilience to aging and

    This manuscript was facilitated by the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), through the ADDRESS! Special Interest Group which was founded to foster international research collaborations to study cognitive reserve and resilience across sex, gender, race, and ethnic diverse ...

  26. Current understanding of Alzheimer's disease diagnosis and treatment

    Alzheimer's disease is the most common cause of dementia worldwide, with the prevalence continuing to grow in part because of the aging world population. ... Research into future treatments of AD involve targeting of the etiologic pathologies: neurofibrillary tangles (composed of p-tau) and senile plaques (Aβ). ... Diseases: Study neuron ...

  27. Study shows 13% of patients with dementia may instead have cognitive

    In the study published in January, the researchers reviewed medical records of 177,422 U.S. veterans diagnosed with dementia but not cirrhosis between 2009 and 2019.

  28. The causes and consequences of Alzheimer's disease: phenome-wide

    Alzheimer's disease (AD) has no proven causal and modifiable risk factors, or effective interventions. We report a phenome-wide association study (PheWAS) of genetic liability for AD in 334,968 ...

  29. Opinion

    Ruth Itzhaki, a research scientist at the University of Oxford, stirred curiosity in the 1990s when she shared evidence tying Alzheimer's to herpesvirus — a scourge spread by oral or genital ...

  30. University of Texas Medical Branch Alzheimer's study shows nasal spray

    The Alzheimer's Association said the crippling neurological disease impacts 7 million Americans. Now, a new study could change everything. The report is authored by The University of Texas Medical ...