integrative literature review a research method to incorporate evidence in health care and nursing

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• Literature Reviews in the Health Sciences
• Review Comparison Chart
• Decision Tools
• Systematic Review
• Meta-Analysis
• Scoping Review
• Mapping Review
• Integrative Review
• Rapid Review
• Realist Review
• Umbrella Review
• Review of Complex Interventions
• Diagnostic Test Accuracy Review
• Narrative Literature Reviews
• Standards and Guidelines

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When is an Integrative Review methodology appropriate?

Outline of stages, methods and guidance, examples of integrative reviews, supplementary resources.

"An integrative review is a specific review method that summarizes past empirical or theoretical literature to provide a greater comprehensive understanding of a particular phenomenon or healthcare problem" (Broome, 1993). Thus, integrative reviews have the potential to build upon nursing science, informing research, practice, and policy initiatives.

An integrative review method is an approach that allows for the inclusion of diverse methodologies (i.e. experimental and non-experimental research) and have the potential to play a greater role in evidence-based practice for nursing ( Whittemore & Knafl, 2005 ).

Characteristics:

• An integrative review is best designed for nursing research
• The problem must be clearly defined
• define concepts
• review theories
• review evidence/point out gaps in the literature
• analyze methodological issues

When to Use It: According to Toronto & Remington (2020) , Whittmore & Knafl (2005) , and Broome (2000)  an integrative review approach is best suited for:

• A research scope focused more broadly at a phenomenon of interest rather than a systematic review and allows for diverse research, which may contain theoretical and methodological literature to address the aim of the review.
• Supporting a wide range of inquiry, such as defining concepts, reviewing theories, or analyzing methodological issues.
• Examining the complexity of nursing practice more broadly by using diverse data sources.

The following stages of conducting an integrative review are derived from  Whittemore & Knafl (2005) .

Timeframe:  12+ months

*Varies beyond the type of review. Depends on many factors such as but not limited to: resources available, the quantity and quality of the literature, and the expertise or experience of reviewers" ( Grant & Booth, 2009 ).

Question:  Formulation of a problem, may be related to practice and/or policy especially in nursing.

Is your review question a complex intervention?  Learn more about  Reviews of Complex Interventions .

Sources and searches:  Comprehensive but with a specific focus, integrated methodologies-experimental and non-experimental research. Purposive Sampling may be employed. Database searching is recommended along with grey literature searching. "Other recommended approaches to searching the literature include ancestry searching, journal hand searching, networking, and searching research registries." Search is transparent and reproducible.

Selection:  Selected as related to problem identified or question, Inclusion of empirical and theoretical reports and diverse study methodologies. 

Appraisal:  "How quality is evaluated in an integrative review will vary depending on the sampling frame." Limited/varying methods of critical appraisal and can be complex. "In a review that encompasses theoretical and empirical sources, two quality criteria instruments could be developed for each type of source and scores could be used as criteria for inclusion/exclusion or as a variable in the data analysis stage."

Synthesis:  Narrative synthesis for qualitative and quantitative studies. Data extracted for study characteristics and concept. Synthesis may be in the form of a table, diagram or model to portray results. "Extracted data are compared item by item so that similar data are categorized and grouped together."  

The method consists of:

• data reduction
• data display
• data comparison
• conclusion drawing,
• verification 

The following resources are considered to be the best guidance for conduct in the field of integrative reviews.

Methods & Guidance

• Hopia, H., Latvala, E., & Liimatainen, L. (2016). Reviewing the methodology of an integrative review .  Scandinavian journal of caring sciences ,  30 (4), 662–669. doi: 10.1111/scs.12327
• Russell C. L. (2005). An overview of the integrative research review .  Progress in transplantation ,  15 (1), 8–13. doi: 10.1177/152692480501500102
• Whittemore, R., & Knafl, K. (2005). The integrative review: updated methodology .  Journal of advanced nursing ,  52 (5), 546–553. doi: 10.1111/j.1365-2648.2005.03621.x

Reporting Guideline

There is currently no reporting guideline for integrative reviews.

• Collins, J. W., Zoucha, R., Lockhart, J. S., & Mixer, S. J. (2018). Cultural aspects of end-of-life care planning for African Americans: an integrative review of literature .  Journal of transcultural nursing ,  29 (6), 578–590. doi: 10.1177/1043659617753042
• Cowdell, F., Booth, A., & Appleby, B. (2017). Knowledge mobilization in bridging patient-practitioner-researcher boundaries: a systematic integrative review protocol .  Journal of advanced nursing ,  73 (11), 2757–2764. doi: 10.1111/jan.13378
• Frisch, N. C., & Rabinowitsch, D. (2019). What's in a definition? Holistic nursing, integrative health care, and integrative nursing: report of an integrated literature review .  Journal of holistic nursing ,  37 (3), 260–272. doi: 10.1177/0898010119860685
• Kim, J., Kim, Y. L., Jang, H., Cho, M., Lee, M., Kim, J., & Lee, H. (2020). Living labs for health: an integrative literature review .  European journal of public health ,  30 (1), 55–63. doi: 10.1093/eurpub/ckz105
• Luckett, T., Sellars, M., Tieman, J., Pollock, C. A., Silvester, W., Butow, P. N., Detering, K. M., Brennan, F., & Clayton, J. M. (2014). Advance care planning for adults with CKD: a systematic integrative review .  American journal of kidney diseases ,  63 (5), 761–770. doi: 10.1053/j.ajkd.2013.12.007
• Shinners, L., Aggar, C., Grace, S., & Smith, S. (2020). Exploring healthcare professionals' understanding and experiences of artificial intelligence technology use in the delivery of healthcare: an integrative review .  Health informatics journal ,  26 (2), 1225–1236. doi: 10.1177/1460458219874641
• Silva, D., Tavares, N. V., Alexandre, A. R., Freitas, D. A., Brêda, M. Z., Albuquerque, M. C., & Melo, V. L. (2015). Depressão e risco de suicídio entre profissionais de Enfermagem: revisão integrative [Depression and suicide risk among nursing professionals: an integrative review] .  Revista da Escola de Enfermagem da U S P ,  49 (6), 1027–1036. doi: 10.1590/S0080-623420150000600020
• Stormacq, C., Van den Broucke, S., & Wosinski, J. (2019). Does health literacy mediate the relationship between socioeconomic status and health disparities? integrative review .  Health promotion international ,  34 (5), e1–e17. doi: 10.1093/heapro/day062
• Broome M.E. (1993). Integrative literature reviews for the development of concepts. In Rodgers, B. L., & Knafl, K. A. (Eds.),  Concept development in nursing  (2nd ed., pp. 231-250). W.B. Saunders Company.
• da Silva, R. N., Brandão, M., & Ferreira, M. A. (2020). Integrative Review as a Method to Generate or to Test Nursing Theory .  Nursing science quarterly ,  33 (3), 258–263. doi: 10.1177/0894318420920602
• Garritty, C., Gartlehner, G., Nussbaumer-Streit, B., King, V. J., Hamel, C., Kamel, C., Affengruber, L., & Stevens, A. (2021). Cochrane Rapid Reviews Methods Group offers evidence-informed guidance to conduct rapid reviews .  Journal of clinical epidemiology ,  130 , 13–22. doi: 10.1016/j.jclinepi.2020.10.007
• Grant, M. J., & Booth, A. (2009). A typology of reviews: an analysis of 14 review types and associated methodologies .  Health information and libraries journal ,  26 (2), 91–108. doi: 10.1111/j.1471-1842.2009.00848.x

Toronto, C. E., & Remington, R. (2020).  A Step-By-Step Guide to Conducting an Integrative Review.  Springer International Publishing AG. doi: 10.1007/978-3-030-37504-1

• Torraco, R. J. (2005). Writing integrative literature reviews: guidelines and examples .  Human Resource Development Review, 4 (3), 356–367. doi: 10.1177/1534484305278283
• Whittemore. (2007). Rigour in Integrative Reviews . In Webb, C., & Roe, B. (Eds.),  Reviewing Research Evidence for Nursing Practice (pp. 149–156). Blackwell Publishing Ltd. https://doi.org/10.1002/9780470692127.ch11
• << Previous: Mapping Review
• Next: Rapid Review >>

Other Names for an Integrative Review

• Integrative Literature Review
• Systematic Integrative Review
• Integrative Research Review

Limitations of an Integrative Review

The following challenges of integrative reviews are derived from Toronto & Remington (2020) , Whitmore & Knafl (2005) , and Broome (2000) .

• The combination and complexity of incorporating diverse methodologies can contribute to lack of rigor, inaccuracy, and bias.
• Methods of analysis, synthesis, and conclusion-drawing remain poorly formulated.
• Combining empirical and theoretical reports can be difficult.
• There is no current guidance on reporting.

Medical Librarian

• Last Updated: Sep 5, 2023 11:14 AM
• URL: https://guides.lib.uh.edu/reviews

Overview of the Integrative Review

• First Online: 18 February 2020

Cite this chapter

• Coleen E. Toronto 3  

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A reviewer selects literature on a topic and synthesizes and disseminates review findings to a targeted discipline. There are many review methods available for a reviewer to consider. The review question(s) will determine which review method is most appropriate to use. If the reviewer seeks to examine a topic broadly and wants to identify the current state of science on a particular phenomenon, an integrative review would be the method chosen. There are limited resources available to a reviewer to access when seeking guidance on how to conduct an integrative review. This chapter provides an overview of the integrative review method and provides a framework for the different steps that are recommended when conducting such a review.

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Conducting a Systematic Review: A Practical Guide

Aromataris E, Munn Z (eds) (2017) Joanna Briggs Institute reviewer’s manual. The Joanna Briggs Institute. https://reviewersmanual.joannabriggs.org/

Aveyard H, Bradbury-Jones C (2019) An analysis of current practices in undertaking literature reviews in nursing: findings from a focused mapping review and synthesis. BMC Med Res Methodol 19:1. https://doi.org/10.1186/s12874-019-0751-7

Article   Google Scholar  

Conner BT (2014) Demystifying literature reviews. Am Nurse Today 9(1):13–14

Google Scholar  

Cooper HM (1982) Scientific guidelines for conducting integrative research reviews. Rev Educ Res 52:291–302. https://doi.org/10.2307/1170314

Cooper HM (1984) The integrative research review: a systematic approach. SAGE Publications, Beverly Hills, CA, p 11

Coughlan M, Cronin P (2017) Doing a literature review in nursing, health and social care, 2nd edn. SAGE Publications, Thousand Oaks, CA, p 12

de Souza MT, da Silva MD, de Carvalho R (2010) Integrative review: what is it? How to do it? Einstein (São Paulo) 8(1):102–106. https://doi.org/10.1590/s1679-45082010rw1134

Denney AS, Tewksbury R (2013) How to write a literature review. J Crim Justice Educ 24(2):218–234. https://doi.org/10.1080/10511253.2012.730617

Ganong LH (1987) Integrative review of nursing research. Res Nurs Health 10(1):1–11

Article   CAS   Google Scholar  

Gough D, Thomas J, Oliver S (2012) Clarifying differences between review designs and methods. Syst Rev 1:28. https://doi.org/10.1186/2046-4053-1-28

Article   PubMed   PubMed Central   Google Scholar  

Grant MJ, Booth A (2009) A typology of reviews: an analysis of review types and associated methodologies. Health Inf Libr J 26:91–108. https://doi.org/10.1111/j.1471-1842.2009.00848.x

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (eds) (2019) Cochrane handbook for systematic reviews of interventions version 6.0 (updated July 2019). Cochrane. www.training.cochrane.org/handbook

Hopia H, Latvala E, Liimatainen L (2016) Reviewing the methodology of an integrative review. Scand J Caring Sci 30:662–669. https://doi.org/10.1111/scs.12327

Article   PubMed   Google Scholar  

Institute of Medicine (2011) Finding what works in health care: standards for systematic reviews. The National Academies Press, Washington, DC. https://doi.org/10.17226/13059

Book   Google Scholar  

Jackson GB (1980) Methods for integrative reviews. Rev Educ Res Rev 50:438–460. https://doi.org/10.2307/1170440

Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62(10):1006–1012. https://doi.org/10.1016/j.jclinepi.2009.06.005

Morris ZS, Wooding S, Grant J (2011) The answer is 17 years, what is the question: understanding time lags in translational research. J R Soc Med 104(12):510–520. https://doi.org/10.1258/jrsm.2011.110180

Oermann MH, Hays JC (2016) Writing for publication in nursing, 3rd edn. Springer, New York, NY, p 136

Polit DF, Beck CT (2018) Essentials of nursing research: appraising evidence for nursing practice, 9th edn. Wolters Kluwer, Philadelphia, p 96

Russell CL (2005) An overview of the integrative research review. Prog Transplant 15(1):8–13. https://doi.org/10.7182/prtr.15.1.0n13660r26g725kj

Soares CB, Hoga LAK, Peduzzi M, Sangaleti C, Yonekura T, Silva D (2014) Integrative review: concepts and methods used in nursing. Rev Esc Enferm USP 48(2):329–339. https://doi.org/10.1590/s0080-6234201400002000020

Toronto CE, Quinn B, Remington R (2018) Characteristics of reviews published in nursing literature: a methodological review. ANS Adv Nurs Sci 41(1):30–40. https://doi.org/10.1097/ANS.0000000000000180

Torraco RJ (2005) Writing integrative literature reviews: guidelines and examples. Hum Resour Dev Rev. SAGE Publications 4(3):356–367. https://doi.org/10.1177/1534484305278283

Torraco RJ (2016) Writing integrative literature reviews: using the past and present to explore the future. Hum Resour Dev Rev 15(4):404–428. https://doi.org/10.1177/1534484316671606

Whittemore R (2007) Rigour in integrative reviews. In: Webb C, Roe B (eds) Reviewing research evidence for nursing practice: in systematic reviews. Blackwell Publishing, Malden, MA, p 151

Whittemore R, Chao A, Jang M, Minges KE, Park C (2014) Methods for research synthesis: an overview. Heart Lung 43(5):453–461. https://doi.org/10.1016/j.hrtlng.2014.05.014

Whittemore R, Knafl K (2005) The integrative review: updated methodology. J Adv Nurs 52(5):546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x

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Coleen E. Toronto

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Toronto, C.E. (2020). Overview of the Integrative Review. In: Toronto, C., Remington, R. (eds) A Step-by-Step Guide to Conducting an Integrative Review. Springer, Cham. https://doi.org/10.1007/978-3-030-37504-1_1

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Integrative literature review of evidence-based patient-centred care guidelines

Affiliations.

• 1 Department of Nursing Science, Faculty of Health Sciences, Nelson Mandela University, Port Elizabeth, South Africa.
• 2 Faculty of Health Sciences, Nelson Mandela University, Port Elizabeth, South Africa.
• 3 Department of Nursing and Midwifery, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
• PMID: 33314226
• DOI: 10.1111/jan.14716

Aim: To summarize what facilitates patient-centred care for adult patients in acute healthcare settings from evidence-based patient-centred care guidelines.

Design: An integrative literature review.

Data sources: The following data sources were searched between 2002-2020: Citation databases: CINAHL, Medline, Biomed Central, Academic Search Complete, Health Source: Nursing/Academic Edition and Google Scholar. Guideline databases: US National Guideline Clearinghouse, Guidelines International Network, and National Institute for Health and Clinical Excellence (NICE). Websites of guideline developers: Scottish Intercollegiate Guidelines Network, Royal College of Nurses, Registered Nurses Association of Ontario, New Zealand Guidelines Group, National Health and Medical Research Council, and Canadian Medical Association.

Review methods: Whittemore and Knafl's five-step integrative literature review: (1) identification of research problem; (2) search of the literature; (3) evaluation of data; (4) analysis of data; and (5) presentation of results.

Results: Following critical appraisal, nine guidelines were included for data extraction and synthesis. The following three groups of factors were found to facilitate patient-centred care: 1) Patient care practices: embracing values foundational to patient-centred care, optimal communication in all aspects of care, rendering basic nursing care practices, and family involvement; 2) Educational factors: staff and patient education; and 3) Organizational and policy factors: organizational and managerial support, organizational champions, healthy work environment, and organizational structures promoting interdisciplinary partnership.

Conclusion: Evidence from included guidelines can be used by nurses, with the required support and buy-in from management, to promote patient-centred care.

Impact: Patient-centred care is essential for quality care. No other literature review has been conducted in the English language to summarize evidence-based patient-centred care guidelines. Patient care practices and educational, organizational, and policy factors promote patient-centred care to improve quality of care and raise levels of awareness of patient-centred care among nursing staff and patients.

Keywords: Evidence-based; best practice guideline; literature review; nurses; patient-centred care.

© 2020 John Wiley & Sons Ltd.

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