how long is a phd md

Is an MD/PhD Program Right for You?

MD-PhD programs may be right for you if you are interested in a career path that melds both clinical practice and in-depth scientific research. MD-PhD graduates aren’t simply doctors; they are “physician-scientists” or “medical scientists.”

MD-PhD programs offer a dual-degree track that combines the clinical training of a standard MD degree with the added coursework of a PhD. The PhD training is particularly rigorous and includes classes usually in the realm of biomedical sciences, as well as advanced research training, lab rotations, and intensive investigative work.

The payoff for choosing an MD-PhD program is that these clinical medicine graduates are equipped to treat patients while also participating in the discovery and development of innovative healthcare solutions. 

Here are a few reasons you might want to pursue an MD/PhD career:

• You want to participate in cutting-edge medical research.
• You want career options beyond clinical medical practice.
• You want to help train future generations of medical doctors.
• You want more collaborative research opportunities with colleagues.
• You want funding opportunities only available to MD/PhD students.

The Difference Between MD & MD/PhD

The difference between MD and MD-PhD is that graduates with an MD-PhD receive PhD training and hold a PhD degree in addition to their MD degree.

The cost of an MD-PhD program varies widely depending on the institution. Still, the stipend and tuition-free training make many of these programs significantly less financially burdensome compared to standalone MD or PhD programs.

MD/PhD students will complete graduate school and medical school qualified to hold positions in academic medicine and biomedical research (in addition to being qualified to practice clinical medicine. 

What Is an MD?

A medical doctor has earned a standard medical degree or MD and is skilled to practice clinical medicine. Medical students must complete 4 years of medical school to earn their degree, followed by 3-7 years of residency and fellowship training to practice medicine.

What Is a PhD?

PhD stands for Doctor of Philosophy in reference to their critical knowledge and research experience in a particular field of study. A PhD is the highest possible academic degree.

Earning a PhD is often considered harder than earning an MD due to the scientific research required to stimulate original thought and develop quality hypotheses.

How Competitive Are MD/PhD Programs?

Physician-scientist programs are slightly more selective and competitive than the average medical program.

Between 2018 and 2023, a little more than one-third of students who applied to an MD/PhD program (37.7%) were accepted. The acceptance rate for medical school applicants in general was 41.2% for the 2022-23 application cycle.

The test scores of these programs also indicate how much more competitive these programs are. The average MCAT score of MD/PhD matriculants in the 2022-23 cycle was 516.2, and their mean GPA was 3.82. In comparison, medical school matriculants overall had an average MCAT score of 511.9 and average GPA of 3.75 during the same cycle.

How Long Are MD/PhD Programs?

The MD-PhD dual degree takes approximately 7-8 years of coursework to complete, followed by an additional 3-7 years of residency to be eligible to practice medicine. 

Generally, MD coursework is emphasized in years 1-2, followed by research training in years 3-5, and ending with medical training and clinicals in years 6-8. 

Requirements for MD/PhD Applicants

If you are considering applying to an MD/PhD program , know that having strong essays and letters is more important than incrementally higher MCAT test scores and GPAs. Numbers get your foot in the door; storytelling gets you a seat at the table. 

In general, the requirements for MD/PhD applicants include:

• MCAT score in the 90th percentile: Specific MCAT requirements for MD/PhD programs vary by school. However, in general, most students have the best chance at success with an MCAT score in the 90th percentile or higher. In the 2022-23 application cycle, MD/PhD applicants had an average MCAT score of 511.3, while matriculants averaged 516.2.
• GPA of 3.7 or higher: Like MCAT scores, the GPA requirements for MD/PhD programs differ by program. But your chances are highest with an average GPA of at least 3.7. In the 2022-23 application cycle, MD/PhD applicants averaged a science GPA of 3.61 and overall GPA of 3.68, while matriculants averaged a 3.78 science GPA and 3.82 overall.
• Compelling personal statement: Your personal statement essay should explain why you want to become a physician and is required for both MD & MD/PhD applications . All prospective doctors must write a personal statement that stands out, and this is doubly true for MD/PhD applicants.
• 2 additional essays: You’ll write one essay conveying your personal interest in pursuing an MD/PhD dual degree specifically, and one essay covering your substantive experiences in the field of research . These may include multiple summer projects, senior thesis research, or 1+ years of post-undergrad research programs and activities.
• 2-3 letters from research mentors who can praise your scientific potential.
• 1-2 letters from clinical mentors who know your aptitude for patient care.
• 1 letter from the premed committee.
• 1 letter from a mentor who can discuss your leadership skills and personal traits in an extracurricular setting.

Questions to Ask Yourself When Considering an MD/PhD Program

By answering these questions, you can choose the graduate program that is the best fit for you over the next 8 years.

• What skills do you want to develop? Choose a program that has ample opportunities to explore your field of interest and in which you can identify potential mentors for rotations and thesis projects.
• What is your preferred MD/PhD program size? Choose a smaller program of MD-PhD students if you prefer hands-on guidance with individualized attention and a larger program if you prefer a larger community with more networking opportunities. 
• Where do you want to live for 8 years of medical school ? Choose a location that fits your needs for cost of living, housing, transportation, extracurriculars, as well as opportunities for fun and making friends. 
• Does the program offer financial aid? Choose a program that meets your financial needs in the form of stipends and tuition waivers. It’s important to note that if you drop out of an MD-PhD program, some schools require you to pay back the investment that the school made in you. 
• Will you fit into the school’s culture? Choose a program after you’ve visited the campus, talked with the current students and faculty, and asked about opportunities in your field of interest as well as other’s experiences at the school and living in the city.
• Does the MD/PhD Program align with your timeline? Choose a program with coursework that allows you to graduate in your preferred timeline, which could be sooner or longer than eight years.

Possible Career Paths for MD/PhD Graduates

A career choice often depends on an individual’s specific interests, such as which medical specialties they are drawn to, whether they prefer working with patients or in a laboratory, and how they want to contribute to advancing medical science.

The salary range for MD/PhD graduates varies significantly by position and type of work. Policy analysts’ starting salary is around $57,000 per year, while attending physicians who do research can make upwards of $500,000.

Below are careers someone with an MD-PhD might pursue:

Attending Physician with Research Responsibilities

An MD/PhD holder in this position would have a traditional medical role seeing and treating patients, but they might also have dedicated time for research. This role allows one to continue practicing medicine while contributing to academic or clinical research. 

Individuals in this role often split their time among patient care, research activities, and instructional duties. Typically, they are found in educational hospitals or medical schools.

Physicians’ salaries can vary significantly based on specialty and experience, but generally, they are well-compensated. An attending physician in a specialized field can expect to earn upwards of $200,000 to $500,000 or more, especially if they have dual responsibilities that include research.

Translational Medicine Specialist

These specialists work at the intersection of basic research and patient care, focusing on turning research insights into practical medical applications. 

This role may exist within academia, industry, or clinical settings and is tailored for those who understand both the clinical and research aspects of medicine.

The salary for this role can also vary based on industry, location, and level of experience but would likely fall in the range of $150,000 to $250,000 or more.

Biomedical Researcher

Those with MD-PhD qualifications commonly secure jobs as researchers within biomedical science. Employment settings can range from academic institutions and drug companies to governmental agencies like the NIH.

Salaries for biomedical researchers typically fall somewhere between $85,000 and $104,000 per year.

Clinical Research Director

These are medical doctors responsible for overseeing clinical trials and research projects, usually within a hospital, academic institution, or pharmaceutical/biotech company. This role leverages both the clinical insights from an MD and the research methodology of a PhD.

Salaries can vary widely depending on the setting (academia, private industry, etc.) and geographic location. In general, a Clinical Research Director could expect to earn a six-figure salary, often ranging from around $150,000 to $250,000 or more per year.

Pharmaceutical/Biotech Industry Professional

A significant number of MD-PhDs join the pharmaceutical or biotech sectors. Responsibilities might include roles in the development of new medications, overseeing clinical trials, regulatory compliance, or managing medical affairs.

The average salary for this position will likely differ quite a bit depending on the exact role and company, but the average is generally between $125,000 and $133,00 per year.

Medical Director

In this capacity, a person is in charge of the medical elements of a healthcare facility or a specific department within a hospital. The role usually calls for expertise in both medical practice and research.

This position is likely to be one of the most lucrative of the MD/PhD field, with an average salary from $319,000 to $329,000 per year.

Science Policy Analyst/Advisor

Individuals in this role often find themselves in governmental or nonprofit settings, where they influence policy decisions related to scientific research and healthcare.

The typical salary for a science policy analyst starts at around $57,000 per year. Advisors have a slightly higher upper salary range and may make as much as $75,000.

Public Health Official

Some MD-PhDs opt for roles in the public sector where they focus on health concerns at a societal level. They may be employed by organizations such as the CDC or WHO.

In many cases, public health officials can expect to make a yearly salary of between $101,000 and $111,000.

Medical Science Liaison

This role typically serves as an intermediary between pharmaceutical enterprises and medical professionals. These liaisons disseminate information about new treatments and scientific advancements to doctors, researchers, and other medical stakeholders.

This role also typically commands a six-figure salary, usually ranging from approximately $100,000 to $200,000, depending on experience, location, and the hiring organization.

Medical Educator

Professors teach medical students, residents, and fellows in an academic setting while also conducting research. These doctors often have clinical responsibilities as well. An MD/PhD is especially well-suited for this role due to the dual focus on clinical care and research.

They may teach various medical subjects like pharmacology or genetics and actively participate in the educational goals of their institutions.

In academia, salaries can vary widely based on rank (Assistant Professor, Associate Professor, Full Professor), institution, and geographic location. Salaries may range from $100,000 to well over $200,000 for senior roles or those at prestigious institutions.

Best MD/PhD Programs in the US

There are 122 different American Universities that offer MD/PhD degree programs, according to the AAMC list of MD-PhD Programs by State . A further 13 Canadian programs also use the AMCAS application system.

Some MD-PhD programs in the United States are funded by the National Institutes of Health (NIH) through the Medical Scientist Training Program (MSTP). This means that students receive full tuition remission, health insurance, and a living stipend throughout their training.

Medical schools with fully funded MD-PhD programs :

• Dartmouth University, Geisel School of Medicine
• Duke University School of Medicine
• Harvard/M.I.T MD-PhD Program, Harvard Medical School
• John Hopkins University School of Medicine
• Mayo Clinic College of Medicine & Science
• University of Florida College of Medicine
• University of Pennsylvania, Perelman School of Medicine
• University of Southern California (USC), Keck School of Medicine
• Yale University School of Medicine

Medical schools with the most MD-PhD spots historically: 

• Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
• University of Illinois College of Medicine
• Weill Cornell Medical College
• Washington University in St. Louis School of Medicine
• Johns Hopkins University School of Medicine
• Albert Einstein College of Medicine of Yeshiva University
• University of California, Los Angeles David Geffen School of Medicine
• University of Michigan Medical School
• Columbia University College of Physicians and Surgeons 
• University of Pittsburgh School of Medicine
• Harvard Medical School
• Case Western Reserve University School of Medicine
• Northwestern University The Feinberg School of Medicine
• Icahn School of Medicine at Mount Sinai
• University of California, San Francisco, School of Medicine
• Vanderbilt University School of Medicine
• Ohio State University College of Medicine
• University of Wisconsin School of Medicine and Public Health
• New York University School of Medicine
• Stanford University School of Medicine
• Yale School of Medicine

Medical schools with MD/PhD programs that accept international students:

• Emory University School of Medicine
• Northwestern Feinberg School of Medicine
• University of Pennsylvania Perelman School of Medicine
• University of Southern California Keck School of Medicine/California Institute of Technology
• University of Texas Southwestern Medical School
• Washington University School of Medicine in St. Louis

The MD/PhD Application Process

The application process for MD-PhD programs is similar to that of typical MD programs. The two major differences are that you’ll designate yourself as an MD/PhD candidate on the AMCAS application, and you’ll submit 2 additional essays on that primary.

The Application Timeline

• AMCAS (submit by end of May): You’ll fill out a primary application through AMCAS in the spring of the first year of your application cycle (e.g., to matriculate in fall 2026, you’ll submit AMCAS in spring 2025). AMCAS opens at the end of May each year. Aim to submit the primary application no later than the end of June, as early applications are more likely to be reviewed and accepted.
• Secondaries (submit by end of August): You’ll respond to secondary applications in the summer after your primary application is reviewed by each school you submitted it to. Each program sends secondary applications to students who generally meet their minimum requirements.
• Interviews (October-March): You’ll then attend interviews as invited between October and March. Some schools won’t contact you at all to reject your application; others will offer conflicting invites. You must prioritize your options and prepare for the opportunities that do come. 
• Final decisions (December-March): Final decisions are made by schools between December and March. Schools with a rolling admissions cycle (most of them) accept students after completing interviews and determining a student is a fit. A smaller number of programs wait to send acceptances until after all interviews are complete.
• Choose your program (March-April): Students choose where to matriculate between March and April.
• Programs start (June-August): Programs begin between June and August, depending on the school.

How to Prepare for an MD/PhD interview

You should prepare for your MD/PhD interview by practicing mock interviews to rid yourself of the jitters and fine-tune your responses in various scenarios. In addition to developing your personal narrative, you must be able to explain your research training at multiple levels.  

If you’re interested in participating in a mock interview with a physician who has served on an admissions committee, consider a mock interview with MedSchoolCoach .

What to Do if You Get Waitlisted

Finding out that you’ve been waitlisted for the MD/PhD program of your dreams is never a good feeling. However, you are not helpless in the wait. It’s a good idea to remain in contact with program leaders and administrators by sending a Letter of Intent or a Letter of Interest.

Listen: An MD/PHD’s Journey to Medicine [PODCAST]  

What is a Letter of Intent vs. a Letter of Interest? 

A Letter of Intent is a formal statement that you would commit to matriculating into a program if you are accepted. A Letter of Interest conveys that you are strongly interested in the program, but it does not indicate any commitment or explicitly state that a program is your first choice.

Both letters should summarize why you believe the program and school are a great fit for your interests and how you will be able to uniquely contribute to the school, in under one page.

Finding Out You’ve Been Accepted!

The day you receive that phone call or email — the one from the MD-PhD program director contacting you to say you have officially been offered acceptance into their program — provides a feeling of joy worth being patient for!

Our Physician Advisors can support you through the application process for your best shot at getting into the school of your choice.

What specialties can MD/PhD graduates earn their PhD in?  

PhD students commonly choose to specialize in topics such as:

• Cell Biology
• Biochemistry
• Pharmacology
• Neuroscience
• Biomedical Engineering

What is the salary range for an MD/PhD graduate? 

MD/PhD graduates can expect an average annual salary of about $100K, depending on the type of work and place of employment.

What is the difference between a PhD and a Postdoctorate? 

A Postdoctoral Fellowship is a temporary period of mentorship and research training for graduates with doctoral degrees, offered by the National Institutes of Health, to acquire skills needed for a chosen career. A PhD thesis must be successfully defended, whereas a postdoc is a non-defendable temporary employment assignment from an organization such as a university.

Can an MD/PhD be a doctor? 

Graduates who earn an MD/PhD are fully qualified doctors and may practice medicine in a clinical setting upon completing their residency training.

Can an MD/PhD graduate be a surgeon? 

While an MD/PhD graduate CAN be a surgeon if they choose surgery specialties in their residency programs, a surgical resident is not required to obtain a PhD in addition to their MD.

Schedule a free 15-minute consultation with MedSchoolCoach to learn how we can help boost your chances of success getting into medical school .

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• Administrators
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MD-PhD Timeline

• Responsible Conduct of Research (RCR)
• Clinical Activities
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• Annual Program Retreat
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• Fellowships Awarded

INFORMATION FOR

• Residents & Fellows
• Researchers

Years 1 and 2

Year 3 and 4 through phd defense.

During the summer following their 6 months of Integrated Clinical Clerkships, MD-PhD students study for and take USMLE Step I. There is also time to complete an additional research rotation, if necessary, and to take a vacation. The Step 1 exam must be taken by December 31 of Year 3. Students meet with their Director of Graduate Studies to formally affiliate with a PhD department and research laboratory at the start of Year 3 and complete program or department-specific coursework, teaching and qualifying examination requirements in Years 3 and 4. A thesis prospectus is submitted in Year 3 or 4, which coincides with participation in the MD-PhD Program’s Grant Writing Workshop to prepare NIH NRSA F30/F31 and other private foundation applications. Students are required to submit a first author paper and successfully write, defend and submit their PhD dissertation before returning to the wards in October or January of their penultimate year of training.

There is a strong emphasis on maintaining engagement in clinical activities during the PhD thesis years of the MD-PhD training. Clinical activity during research years is an explicit part of the IDP review process, and thesis advisors are informed that this is an encouraged training activity for dual-degree candidates. Most students participate in one or more longitudinal clinical experiences (LCEs) or the student-run “Wednesday Evening Clinic” (WEC) for which they receive elective credit. A student-organized monthly Clinical Reasoning Seminar employs a clinical case-based approach to review diagnosis, pathology and treatment/management with a clinical faculty expert. In addition to maintaining clinical fluency, customized LCEs allow students to explore clinical (sub)specialties related to their research work and interests and are precepted by physician-scientists whenever possible. These experiences allow students to gain a richer understanding of possible career paths for physician-scientists and expose them to the advantages and challenges of combining research with clinical care. Strategies to manage wellness and resilience in a physician-scientist career are discussed during annual program retreats and recurring Brown Bag lunch discussions, while a Curriculum in Leadership and Research Management for Physician-Scientists provides ongoing career development training and experiential learning to MD-PhD students.

Re-entry and Final Year

Md-phd timeline.

MSTP MD-PhD Program

Frequently asked questions.

• Program Structure

How long does it take to complete both degrees?

The average length of time before graduation is 7.5 years; generally students will take 6 years or 8 years depending on the nature of their graduate research. Students generally complete and defend their PhD thesis before completing their clinical rotations in the last 1 – 2 years.

Can I do one degree before the other?

As above, nearly all students will complete their PhD requirements 1 – 2 years before their MD requirements. An important advantage of combined degree training is the breadth that the first 1 – 2 years of medical school provides for graduate research.  Students must pass part I of the National Board Medical Licensing Examination before commencing full-time laboratory research. Occasionally circumstances will arise when an individual student's training is best served by deviating from this "traditional" plan; these situations require approval and monitoring by the graduate advisor and the MSTP Directors.

How will I be supported during my training?

Stanford MSTP students are fully supported through the entire program, tuition, health insurance and stipend, by a combination of funds from a National Institute of Health training grant, individual graduate programs, and School of Medicine funds.

Are there laboratory rotations?

One of the ways in which we try to make the total time of training less than the sum normally taken to complete MD and PhD degrees is by encouraging MSTP students to choose a potential thesis advisor without a yearlong set of rotations through different laboratories. During the first year of the program, students meet with departmental chairs and research faculty and participate in research seminars and group meetings, so that the summer following the first year can be spent working full-time in a laboratory whose goals, approaches, and personnel are already familiar. In most cases, MSTP students choose this laboratory as the place to carry out their thesis research.

Can I get advanced placement credit for graduate coursework?

MSTP students fulfill the same curricular requirements as "straight MD" and "straight PhD" students. Some PhD Programs may permit substitution of previous graduate course work (or MD courses) for their PhD requirements; this is individual to the program and the student.

Are MSTP students required to complete the MD Scholarly Concentration (SC) program?

The MSTP is a combined effort between the MD program and the PhD programs. All trainees are required to fulfill all requirements for both the MD and PhD degrees. The single exception is the MD program requirement for a Scholarly Concentration. For dual degree MD-PhD students, the PhD substitutes for this requirement.

Will I have special opportunities as an MSTP student?

Yes! In addition to individual regular advising meetings with the Program Directors, we hold seminars, courses, and lunches with guest speakers, covering important topics of professional development and translational medicine.  The MSTP community also meets annually for the MSTP Scientific Conference, to present research, and to share clinical experiences, advice and above all support.

Will I have special responsibilities as an MSTP student?

Of course! Besides the challenge of balancing graduate and medical training, we ask all MSTP students to play an integral role in the recruitment, education, and evaluation of incoming MSTP applicants.

Graduate Programs

Can I get a PhD outside the Medical School?

Yes.  One of the unique aspects of the Stanford MSTP is its close affiliation with departments in other Schools, including Engineering (Bioengineering, Chemical, Computer Science, Electrical) and Humanities and Sciences (Biology, Chemistry, Physics, Statistics).

Can I get a PhD in a clinical department?

The PhD must be conferred by a degree-granting department or program, and most clinical departments do not grant PhD degrees. However, most scientists in clinical departments either have joint appointments with basic science departments or are members of interdepartmental programs such as Cancer Biology, Neurosciences, or Immunology, and the only restriction regarding thesis advisors is that they must be members of the Academic Council.

Can I apply to the MSTP and get a PhD in a social science?

If you are a current Stanford MD student and have previously been admitted to a social science PhD program, you may apply to the MSTP for funding.  Admitted PhD candidates may apply through the MSTP internal admissions process.

Are there teaching requirements?

The MSTP itself has no specific teaching requirements, but some PhD programs do.

How will my training differ from other "straight PhD" students?

The short answer is, "It won't." PhD training for MSTP students is just as rigorous and intensive as for students outside the MSTP. However, MSTP students don't spend their first year rotating through different laboratories, and most MSTP students complete their preclinical medical school curriculum before starting full-time laboratory research.

• Admissions Process

How many applicants do you interview and admit?

On average, we invite about 60 students for interviews or about 1 in 9 of those students who submit a secondary application. About 8 - 10 students begin the MSTP every year.

Can I apply to the MSTP after starting medical school?

Yes! One of the unique aspects of the Stanford School of Medicine is its strong emphasis on research, and the MSTP invites current Stanford medical students in their preclinical years, who have made a commitment and contribution to a research-based career, to submit an application for the MSTP.  We refer to this as the “internal” application process . Typically, the MSTP admits 1 – 2 internal applicants every year.

Is there an early decision program?

No. We think making a decision about combined medical school and graduate training is challenging enough! Finding a program that best matches an individual student's interests and goals is facilitated by visiting several universities and meeting with a variety of potential research advisors.

How do I find out about the status of my application?

Just ask (we don't mind).

Can I schedule my interview for a different day?

There are 5 – 6 interview days per season; once invited, interviews are scheduled on a first-come, first-served basis.  We will try to accommodate requests for other dates if necessary.

I don't know whether to apply for Med School or MSTP?

You should only apply to the MSTP if you are committed to a career in biomedical research; such a commitment should be based, in part, on previous sustained and productive research experience as an undergraduate. If you're not sure, consider working full-time in a laboratory after undergraduate school before deciding whether an MSTP is right for you, or, alternatively, starting as a "straight MD" student, participating in a research project in your 2nd or 3rd year, and possibly applying to the MSTP as an internal applicant (see above).

What does the MSTP Admissions Committee look for?

Besides qualification for admission to the medical school itself, the single most important component of an MSTP application is a previous sustained and productive research experience.

When can I expect to hear about the outcome of my application and/or interview?

Interview season is October – February; interview invitations will be issued 3 – 6 weeks before the scheduled interview date. MSTP admission decisions are made on a modified rolling basis.

Are MSTP applicants considered independently for medical school admission?

The MSTP Admissions Committee is separate from, but closely integrated with, the Medical School Admissions Committee.  All applicants to the MSTP are also considered for MD-only admission.  If you are not chosen for an MSTP interview, your application is automatically routed for MD-only consideration.  If you are chosen for an MSTP interview, you will also be required to participate in the MD admission interview process.  These interviews will be scheduled the day before, or day after, your MSTP interviews.  If you are not offered admission to the MSTP, you will be considered for MD-only admission.

• Student Life

Can I afford to live in Palo Alto?

Housing costs in the Bay Area are more than other cities. However, every new graduate student is guaranteed housing on campus or at University associated off-campus sites.  Almost anyone can afford to live comfortably as a Stanford graduate student solely on stipend support.

Will the program pay for health insurance? What about the rest of my family?

We consider health insurance an essential component of all graduate training programs. The program covers the entire cost for individual students and offers a mechanism for subsidizing dependents.

Isn't there more to do in San Francisco than in Palo Alto?

It depends whether you would rather watch street vendors in Union Square or go hiking in the Los Altos foothills. Seriously, downtown San Francisco is a short train ride away from Stanford, but the two environments offer different (and complementary) experiences. Downtown Palo Alto doesn't have skyscrapers but it does have a thriving economy, a diverse population, and an environment that attracts many students to stay here for postgraduate training and career opportunities. Come see for yourself!

• Graduate Program

• PhD vs MD – Differences explained
• Types of Doctorates

A MD is a Doctor of Medicine, whilst a PhD is a Doctor of Philosophy. A MD program focuses on the application of medicine to diagnose and treat patients. A PhD program research focuses on research (in any field) to expand knowledge.

Introduction

This article will outline the key differences between a MD and a PhD. If you are unsure of which degree is suitable for you, then read on to find out the focuses and typical career paths of both. Please note this article has been written for the perspective of a US audience.

What is a MD?

MD (also seen stylized as M.D and M.D.) comes from the Latin term Medicīnae Doctor and denotes a Doctor of Medicine.

MDs practice allopathic medicine (they use modern medicine to treat symptoms and diseases). A common example would be your physician, though there are numerous types of medical doctors, with different areas of speciality and as such may be referred to differently.

What is a PhD?

A PhD (sometimes seen stylized as Ph.D.) comes from the Latin term Philosophiae Doctor and denotes a Doctor of Philosophy.

A PhD can be awarded for carrying out original research in any field, not just medicine. In comparison to an MD, a PhD in a Medicinal field is focused on finding out new knowledge, as opposed to applying current knowledge.

A PhD in Medicine therefore does not require you to attend medical school or complete a residency program. Instead, you are required to produce a thesis (which summarizes your research findings) and defend your work in an oral examination.

What is the difference between a MD and a PhD?

Both are Doctoral Degrees, and someone with either degree can be referred to as a doctor. But for clarity, MDs are awarded to those with expertise in practicing medicine and are therefore more likely to be found in clinical environments. PhDs are awarded to researchers, and are therefore more likely to be found in academic environments.

This does not mean that MDs cannot pursue a research career, nor does it mean that a PhD cannot pursue clinical practice. It does mean, however, that PhDs are more suited to those who would wish to pursue a career in research, and that MDs are more suited to those who prefer the clinical aspects of medicine or aspire to become a practicing physician.

It should also be noted that a medical PhD doctorates possess transferable skills which make them desirable to various employers. Their familiarity with the scientific method and research experience makes them well suited to industry work beyond medical research.

Program structure and time

The standard MD program structure sees students undertake 2 years of coursework and classroom-based learning, before undertaking 2 years of rotational work in a clinical environment (such as a hospital). Getting an MD requires attending a medical school (accredited by the Liaison Committee on Medical Education) and completing a residency program. Both of which prepare students to diagnose patients and practice clinical medicine.

The standard PhD program lasts 5 to 7 years and sees students undertake original research (monitored by a supervisor). Getting a PhD requires the contribution of novel findings, which leads to the advancement of knowledge within your field of research. With the exception of some clinical PhDs, a PhD alone is not enough to be able to prescribe medicine.

PhD doctorates are required to summarize the purpose, methodology, findings and significance of their research in a thesis. The final step is the ‘ Viva Voce ’ where the student must defend their thesis to a panel of examiners.

To summarize, a MD program usually lasts 4 years, whilst a PhD program lasts 5 to 7 years. Before being licensed to practice medicine, however, you must first complete a residency program which can last between 3 to 7 years.

What is a MD/PhD?

A MD/PhD is a dual doctoral degree. The program alternates between clinical focused learning and research focused work. This is ideal for those who are interested in both aspects of medicine. According to the Association of American Medical Colleges, an estimated 600 students matriculate into MD-PhD programs each year .

The typical length of a MD/PhD program is 7 to 8 years, almost twice the length of a MD alone. As with a MD, MD/PhDs are still required to attend medical school and must complete a residency program before being able to practice medicine.

In comparison to PhD and MD programs, MD/PhD positions in the United States are scarce and consequently more competitive. The tuition fees for MD/PhD positions are typically much lower than MD and PhD positions are sometimes waived completely.

Those who possess a MD/PhD are commonly referred to as medical scientists. The ability to combine their medical knowledge with research skills enables MD/PhDs to work in a wide range of positions from academia to industrial research.

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• v.29(8); 2018 Apr 15

Is an MD/PhD program right for me? Advice on becoming a physician–scientist

We are living in a golden age of biomedical research in which it is increasingly feasible to translate fundamental discoveries into new diagnostic and therapeutic approaches to human illnesses. Inherited diseases are being cured with gene therapy. Cancer cells are being eliminated with less toxic small molecule inhibitors and reengineered T-cells. Direct connections are being made between the central nervous system and prosthetic devices. These efforts are being led by scientists and engineers, some of whom are also physicians. This article is intended to help anyone considering a career as a physician–scientist, but unsure about how best to begin. It is also intended for faculty, staff, and parents who are on the front lines of advising talented students about the options that they have for their future. With this in mind, I have tried to answer common questions about MD/PhD programs, but I have also included information about other paths to becoming a physician who does research.

INTRODUCTION

Because this is a perspectives piece, I will begin it with a confession: I have been a physician–scientist for more than 30 years and I like what I do. I am also a graduate of one of the earliest MD/PhD programs and have been director of the University of Pennsylvania’s MD/PhD program for 20 years. Being a physician who is also a scientist already makes me atypical. According to the American Medical Association, only 14,000 U.S. physicians (out of nearly 1 million) consider research to be their major job, and a search of National Institutes of Health (NIH) databases in 2012 turned up only 8200 physicians who were principal investigators on NIH research grants ( Ginsburg et al. , 2014 ). To put that number in context, there were 28,000 total investigators with NIH grants in 2012. In other words, most NIH principal investigators are PhD scientists, not physician–scientists (MD or MD/PhD).

My primary day (and sometimes night and weekend) job as a card-carrying physician–scientist is overseeing an NIH-funded research team. My clinical responsibilities include taking care of patients with the kinds of bleeding and blood clotting disorders that we study in the lab. Some of these patients have medical problems that are common in the United States. Some of them are true “zebras,” the kinds of patients who get referred to a well-respected academic medical center because physicians are unsure how best to proceed or lack the resources to manage the patient’s problem. I also teach medical students and graduate students, and I direct a very large MD/PhD program. In my spare time, I talk to lots of undergraduates and recent college graduates who are thinking about becoming physician–scientists and wondering whether they should be applying to MD/PhD programs. I meet them at Penn, but also on visits to other colleges and universities. This article is a distillation of some answers to questions that I am commonly asked. If you are an undergraduate trying to decide whether to go to medical school, graduate school, or both, this article may help you. Whatever you decide, I wish you success.

WHAT IS THE PURPOSE OF MD/PhD TRAINING?

MD/PhD programs were established in the 1950s to combine training in medicine and research. They were specifically designed for men and women who wanted to become research physicians, also known as physician–investigators or physician–scientists. Most of the graduates of MD/PhD programs in the 60-plus years since then have become faculty members at medical schools and universities, investigators at research institutes such as the NIH, or leaders in in the pharmaceutical and biotech industries ( Brass et al. , 2010 ). Regardless of where they eventually end up, MD/PhD trainees are being prepared for careers in which they will spend most of their time doing research or translating that research into new therapeutic and diagnostic approaches. It is a busy, challenging, and hugely rewarding career. A study of what has happened to MD/PhD program graduates from 24 schools appeared in Academic Medicine in 2010 and is worth reading not only for the data set, but also for the discussion of what the data mean ( Brass et al. , 2010 ). An even larger outcomes study that includes data on over 10,000 MD/PhD program graduates is scheduled for publication as a AAMC report in April 2018 ( Akabas et al. , 2018 ).

HOW CAN ONE PERSON DO TWO JOBS?

When I was an undergraduate and trying to decide what to do with my life, my mentors told me that I could become a doctor or a scientist, but that trying to combine two busy professions was futile. Many years later, I know that many current undergraduates are being told the same thing. However well-meant, that advice misses the point. The goal of MD/PhD program training is not to prepare you for two unrelated full time jobs. Instead, you should think of physician–scientists as chimeras—blends of a physician and a scientist with the two parts fitting closely together. A more relevant question is: if you are going to become a physician–scientist, do you have to go through an MD/PhD program? I will try to answer that one a bit later in this article. First, I’ll provide some definitions.

WHAT IS THE DIFFERENCE BETWEEN AN MD/PhD PROGRAM, A COMBINED DEGREE PROGRAM, AND AN MSTP PROGRAM? A BIT OF HISTORY AND A WORD ABOUT FUNDING

None. Programs designed to train physician–scientists go by all of these names. For the most part, the terms are interchangeable, although at some schools “combined degree” programs can include MD/JD and MD/masters programs as well—also VMD/PhD programs, which train veterinary physician–scientists. A list of MD/PhD programs can be found at http://www.aamc.org/students/research/mdphd/applying_MD/PhD/61570/mdphd_programs.html . The NIH uses the term MSTP (short for “medical scientist training program”) to refer to programs at schools that have been competitively awarded special training funds to help support MD/PhD candidates. There are currently 46 MD/PhD programs that receive support from the National Institute of General Medical Studies. A list can be found at http://www.nigms.nih.gov/Training/InstPredoc/PredocOverview-MSTP.htm .

When they first started, there were only a handful of MD/PhD programs. I can clearly remember reading a small booklet about applying to medical school that had a single page at the back about MD/PhD programs. Over time, the number of programs has grown. Now there are ∼90 active MD/PhD programs that admit anywhere from a few students per year to 25 or more. The average size of an MD/PhD program in 2017 was ∼90 students in all stages of training. Compared with the many thousands who apply to medical school in each year, only 1900 (∼3%) apply to MD/PhD programs. About one-third of the applicants are accepted, which is similar to the acceptance rate for medical school. 1 When I began medical school, there were very few MD/PhD trainees—I was one of two in my entering class. That has changed considerably. There are currently ∼5500 men and women in training in MD/PhD programs.

Most MD/PhD programs provide tuition waivers for both medical school and graduate school plus a stipend to help cover living expenses. Such fellowships are exceedingly valuable for trainees and very expensive for medical schools and the NIH, so admissions committees work hard to pick the right students for their programs. Despite the high training costs, when I visit other MD/PhD programs to conduct reviews, it is not uncommon to hear deans refer to their MD/PhD program as “the jewel in the crown.” One can easily argue that the existence of MD/PhD programs is evidence of the high value that our society places on physician–scientists.

ARE MD/PhD PROGRAMS LIMITED TO THOSE INTERESTED IN LABORATORY RESEARCH?

The answer varies from school to school. Not all schools offer PhD programs in all disciplines. The majority of MD/PhD students receive their PhD in biomedical laboratory disciplines such as cell biology, biochemistry, genetics, immunology, pharmacology, neuroscience, and biomedical engineering. The names of departments and graduate programs vary from school to school. At some schools, MD/PhD trainees do their graduate work outside of the laboratory disciplines, in fields such as economics, epidemiology, health care economics, sociology, medical anthropology, or the history of science. This is not an exhaustive list, and you should check before you apply to see what is actually offered at any particular school.

Although there is no fully up-to-date and reliable list of which MD/PhD programs offer training in which graduate disciplines, a place to start is at the Website of the AAMC MD/PhD section (which is a good source for other types of information as well). 2

ARE THERE OTHER WAYS TO BECOME A PHYSICIAN–SCIENTIST?

Yes. Definitely. MD/PhD programs are a great choice for people who decide early that that they want to be physician–scientists and have built the necessary track record of academic success and research experience before they apply. Not everyone does this, however, either because he or she did not learn about the option early enough, he or she did not make a decision in time, or he or she does not have an academic and research experience record that supports an application. Not finding out early enough turns out to be a common problem. In my experience, college prehealth advisors know much less about MD/PhD training than MD training—not surprisingly, since only 3% of medical school applicants in the United States every year apply for MD/PhD training. As a result, some people choose (or are obliged) to do MD/PhD training in series, rather than parallel—finishing one degree and then starting the other. The disadvantages of this approach include taking longer to finish training and the likely need to cover the cost of medical school on your own.

I am frequently asked about the strategy of starting medical school and then applying to graduate school as a medical student. Some schools will consider you for transfer into their MD/PhD programs after you have completed a year or two of medical school or graduate school at the same university. Although it is very rare that an MD/PhD program will consider accepting a medical or graduate student from a different school, it does occasionally happen when faculty move from one institution to another and want to bring their students with them. The rules and requirements vary from school to school.

Other programs worth checking out include the NIH MD/PhD program that provides support for the PhD phase at the NIH campus or in Oxford/Cambridge, with the MD training taking place at one of the participating MSTP-designated programs. Note that not all of the MSTP programs have chosen to participate, so if you have your heart set on a specific medical school, you should be sure to ask. 3

Another option is to complete medical school and residency training before doing an extended period of supervised research. A number of Nobel Prize–winning physician–scientists did just that. However, with the increase in the number of MD/PhD training programs nationwide, most people who make the decision to become physician–­scientists while still in college should think hard about doing both degrees together in an integrated MD/PhD program that combines graduate school and medical school into a joint program that currently takes 8 years on average to complete ( Akabas et al. , 2018 ).

DO I REALLY NEED A PhD TO DO RESEARCH? CAN I SAVE TIME BY SKIPPING IT?

The answer to the first of these questions is “Clearly not.” However, while medical school will put you firmly on the path to becoming an accomplished clinician, it does not provide training in how to do research. At some point you will benefit from that additional piece of your education if you intend to become a physician–scientist.

As noted above, in years past it was not uncommon to learn how to do research by doing an extended postdoctoral fellowship after (or instead of) a clinical residency. I am often asked whether it is possible to save time on the path to becoming a physician–scientist by skipping graduate school and just going to medical school. The available data suggest that the answer to this one is “No.” Physician–scientists get their first jobs in academia and their first independent NIH grants at approximately the same age regardless of whether they completed an MD/PhD program or went solely to medical school and then did a more extended postdoc ( Ginsburg et al. , 2014 ). As a result, I normally tell undergraduates that if they are ready to make the commitment before starting medical school, MD/PhD programs offer many advantages, including integrated training, mentored research training, and medical school tuition waivers. On the other hand, if you are sure you want to be a doctor, but less sure about being a scientist, then my advice is to go to medical school and figure out the rest of what you need when you know more about the opportunities that being a physician provides.

HOW DOES MD/PhD TRAINING WORK AND HOW LONG DOES IT TAKE?

The answer varies from school to school, but historically students begin with 2 years of medical school, switch to graduate school in the third year of the program, and then return to finish medical school after completing (and defending) a thesis research project. When I was an MD/PhD student in the 1970s, there was little, if any, communication between the medical and graduate phases of the program. That has changed considerably. Now most programs emphasize integration of the MD and PhD parts of the training, with graduate school courses during years 1 and 2 and clinical experiences during graduate school. Some programs allow completion of 3–12 months of clinical training before the start of full-time graduate training. Be sure to ask how things are organized at schools that you are considering. In programs leading to a PhD in laboratory science, MD/PhD trainees usually spend the summer between the first and second years of medical school working in the laboratory of the faculty member they are considering as a potential thesis advisor. Some programs also ask students to do one of these “lab rotations” in the summer before starting medical school classes as well. Depending on the number of clinical months completed before starting the thesis research, students returning to medical school will need 1–2 years to finish their training and meet the requirements for medical licensure. The stated goal is to complete an MD/PhD program in 7 or 8 years. However, numbers from across the country show that some students finish in 6 years, while others take 10 years (or more). The average currently is 8 years ( Akabas et al. , 2018 ). Note that medical education in the United States continues to evolve. One trend is away from the classic two years of preclinical education followed by 2 years of clinical education. The earlier start in clinical training made possible by shortening preclinical time enables some MD/PhD programs to offer full-time clinical experiences before the start of graduate school. However, some schools are choosing not to do this. The only way to find out what is being done is to ask, if it is not evident from the program’s Website.

HOW LONG DOES IT TAKE TO COMPLETE TRAINING AFTER GRADUATING FROM AN MD/PhD PROGRAM?

Corny as this may sound, the process is never really finished. Your education will continue throughout your career. A more pragmatic answer is that training will extend beyond medical school and graduate school as you complete your post graduate education. Here are some typical numbers: MD/PhD program, 8 years. Residency, 3–6 years. Postdoctoral fellowship, 3–6 years. For most people the term “postdoctoral fellowship” includes another year or two of clinical training, followed by a return to research for 2 or more years ( Figure 1 ). For example, I completed an MD/PhD program in 6 years, followed by a residency in internal medicine (3 years) and a fellowship in clinical hemato­logy and oncology that was combined with postdoctoral training back in a lab (3 years). After that I became an assistant professor and started my own lab. That timing was fairly typical when I did it. Now it would be considered fast. On the other hand, my job description when I finished included running a research team, looking after postdocs and graduate students, and taking care of sick people with complicated medical problems, so maybe all of that training time was necessary.

Paths to becoming a physician who is also a scientist. Integrated MD/PhD training programs that combine research and medical training are not the only path to becoming a physician–scientist. Alternatives begin with doing a research year in medical school (MD+ in the figure) or just doing the standard four-year medical school education. These save time at the start, but usually require a longer period of postgraduate clinical and research training to reach the point where a job as a physician–scientist in academia becomes feasible. As a result, physician–scientists often arrive at the “get a job” point at about the same age whether they began as medical students, MD+ students, or MD/PhD students, although usually with greater student debt if they have not been in an MD/PhD program. See the text for details.

WHAT HAPPENS TO THE GRADUATES OF MD/PhD PROGRAMS?

Short-term, nearly all do additional clinical training. Those who do not are usually headed toward careers at research institutes or outside clinical medicine entirely. Those who do apply for residencies often find that their MD/PhD training makes them particularly appealing to residency programs at top institutions. Long-term, most program graduates end up with careers in which they combine patient care and research. The research may be lab-based, translational, or clinical. Most (75–80%) end up at academic medical centers, at research institutions such as the NIH, or in the pharmaceutical/biotech industry ( Figure 2 ; Brass et al. , 2010 ; Akabas et al. , 2018 ). A much higher percentage of MD/PhD program graduates have ended up in academia than of medical school graduates in general ( Brass et al. , 2010 ). Those who build research careers and apply for NIH research grants find that having the PhD in addition to the MD improves their chances of obtaining funding ( Ginsburg et al. , 2014 ).

Where are they working? Data from 2202 MD/PhD program alumni who have completed all phases of postgraduate clinical and research training. Adapted from Brass et al. (2010) . Industry includes the biotech and pharmaceutical industries. Pvt Practice refers to full-time clinical practice outside of an academic medical center.

HOW DO I APPLY?

The process of application varies from school to school. Some schools have an MD/PhD-focused committee that will screen your application and coordinate the interview and admission process. Other schools consider MD/PhD applicants only after a decision has been made about MD admissions. Finally, some schools consider students for the MD/PhD program only after they have completed a year or more of medical school. Schools that subscribe to AMCAS will ask you to indicate your interest in an MD/PhD program and then to provide additional information as part of a secondary application.

WHEN DO I APPLY?

Most people apply after finishing their junior year in college, but a growing number of applicants finish college and work for a year or more before applying. Some people use the time after college to take courses needed for medical school admission or to gain more full-time laboratory research experience. Some people simply were not ready to make decisions about their future careers and postponed choosing beyond the finish of college. It is a mistake to assume that MD/PhD programs are interested only in applicants who have worked in a lab for a year or more after college. That is clearly not the case, and some of us who direct MD/PhD programs are concerned about the growing percentage of applicants who have waited to apply after they graduate in the mistaken impression that it will improve their resumes. My advice is that for a training path that lasts as long as this one does, it is best to get started as soon as possible.

WHAT DO ADMISSIONS COMMITTEES LOOK FOR?

The answer clearly varies from school to school, but some basic principles apply. In general, admissions committees will look for evidence of academic success, extended research experience, letters of recommendation from people who know you well, and your plans for the future.

• Evidence of academic success. This includes your GPA and MCAT scores, but is not limited to them. Admission committees use a holistic approach and will undoubtedly consider where you went to college and what types of courses you took. They will not necessarily be dismayed if you got off to a slow start, as long as you did well later. They will place the greatest emphasis on courses that are relevant to your chosen area of graduate school training. I have not encountered a program director who seriously believed that the MCAT tests your ability to be a physician–scientist. Nonetheless programs use MCAT scores in a variety of ways, including seeing how you compare with the national pool of applicants and predicting how you will do on the numerous standardized tests that all of us have to take in medical school and beyond.
• Extensive research experience. If you plan to get a PhD in one of the laboratory sciences, then prior laboratory experience counts heavily, particularly if you spent a year or more in the same laboratory. Summer laboratory experience can be helpful because they are usually opportunities to do research full time, but summers are short. Whenever possible, you should try to do research during the academic year, or at least spend multiple summers in the same lab. If you are planning a PhD outside of the laboratory sciences, seek equivalent experiences. The idea is to be sure you like the experience and to create a track record upon which your past performance can be judged and your future success predicted.
• Letters of recommendation. The most important letter(s) are from the faculty members or other senior investigators with whom you worked. The letters should ideally comment on your talents, skills, and potential for success as an independent investigator. If you are working with a senior faculty member, it is very helpful if he or she can compare you with other students with whom he or she has worked. Note that such a letter is not necessarily the most appropriate for an MD-only application. MD/PhD program admissions committees are usually most interested in your talent and ability as a physician–scientist, although they will definitely also consider whether you are likely to become a successful and caring physician. Fortunately, medical schools allow you to submit more than one letter of recommendation.
• Your plans for the future. Because training to be a physician–­investigator is so costly in terms of your time and the school’s resources, your career goals should be compatible with MD/PhD training. Becoming a full-time practitioner is a laudable goal, but does not require a PhD in addition to an MD. Your goal as a trained physician–investigator should be to spend at least 75% of your time on research. You do not need to know the specific problem you want to work on at this point (many do not, and it is likely to change), or with whom you would like to train, but your commitment to becoming an investigator should be clearly communicated in your essays and interviews, and you should have given thought to what will be required.

HOW DO I DECIDE WHERE TO APPLY?

Some applicants have decided that they want to work in a particular field or with a particular faculty member. For them, choosing where to apply is defined by where that faculty member works or where the field is best represented. Most applicants have only a general idea of what they might want to work on in the future and know that their interests are likely to evolve as they are exposed to new things. For them, choice will be defined by issues such as the reputation of the school (hopefully not based solely on U.S. News and World Report rankings!), the success of the graduates of the program (be sure to ask!), and geography. Schools vary in the difficulty of gaining admission. The directors and nonfaculty administrators of MD/PhD programs nationwide are a large pool of resources that you can tap. Most of us get e-mail from future applicants all the time. Take advantage of our willingness to talk with you. Ask questions about the things that are important to you.

FINAL THOUGHTS

I began this perspective with the confession that I am a physician–scientist and I like what I do. It is not unusual these days to encounter articles and opinion pieces that lament the difficulty of becoming and remaining a physician–scientist. I will not cite them here—you can find them on your own. Fortunately, our society is still willing to make a large investment in biomedical research through the NIH and through numerous foundations. If you want to become a physician who discovers the new stuff, there are jobs waiting to be filled. However, you will need good training and great mentorship as you learn the skills needed to be a physician and a research team leader. Good luck with your decision.

Acknowledgments

My thanks to my colleagues who direct MD/PhD programs, the NIH for supporting physician–scientist training (including my own), and the hundreds of MD/PhD candidates and alumni who have taught me so much over the past 20 years.

Abbreviations used:

DOI: 10.1091/mbc.E17-12-0721

1 www.aamc.org/data/facts/enrollmentgraduate/ .

2 www.aamc.org/students/research/mdphd/ .

3 http://mdphd.gpp.nih.gov .

• Akabas MH, Tartakovsky I, Brass LF. (2018). The National MD–PhD Program Outcomes Study. American Association of Medical Colleges Reports.
• Brass LF, Akabas MH, Burnley LD, Engman DM, Wiley CA, Andersen OS. (2010). Are MD–PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD–PhD programs . Acad Med , 692–701. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Ginsburg D, Shurin SB, Mills S. (2014). NIH Physician–Scientist Workforce (PSW) Working Group Report. [ Google Scholar ]

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Professor Dr. Thomas Rademacher, MD, PhD, is CEO and Co-Founder of Emergex ( https://emergexvaccines.com/ ), a company that has developed a novel nanoparticle-based vaccine technology to deliver synthetic viral fragments via microneedles on a skin-adhesive patch. Emergex’s approach works on the principle of priming immune T-cells, opening the door for the development of universal vaccines against highly mutagenic viruses such as the seasonal flu and covid. T-cell priming offers a superior inoculation strategy over traditional vaccines, which rely on the body’s generation of antibodies and fail to keep up with seasonal mutations. A serial entrepreneur, Professor Rademacher also serves as Emeritus Professor of Molecular Medicine at University College London (UCL) and is widely considered one of the founders of biotech from the early 1980s (having been involved in many of it’s core disciplines – from recombinant proteins, to monoclonal antibodies, to glycobiology). Professor Rademacher has authored over 200 publications and 50 patents – 19 of which are in the nanomedicine field. In addition to being a world leader in nanomedicine, he is also an expert in fetal-maternal medicine, having produced 25 publications and filed 5 patents related to preeclampsia. Professor Rademacher was co-Founder of the field of Glycobiology and subsequent Glycobiology Institute in Oxford and co-founded Oxford GlycoSciences, the first of Oxford University’s biotech spinouts, which, in 1998, was listed on the London Stock Exchange and reached a market capitalization of £1.7 billion. After moving to UCL, Professor Rademacher founded several biotech spin-out companies, including Rodaris Pharmaceuticals Ltd. In 2000, Professor Rademacher entered into a collaboration with the Spanish Research Council and co-founded the first nanomedicine company, Midatech Ltd. Midatech floated on the AIM and NASDAQ stock exchanges in December 2015.  Support the show

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Career Paths for MD-PhD Graduates

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Information about the career path of a physician-scientist, including training, residency or fellowship, research residency programs, and time commitment.

According to a study by the National Association of MD-PhD Programs, about 75 percent of U.S. MD-PhD graduates are in academic medicine or pharmaceutical company positions that make use of their interests in both patient care and research.

A MD-PhD physician-scientist is typically a faculty member at an academic medical center who spends 70-80 percent of their time conducting research, though this can vary with specialty. Their research may be lab-based, translational, or clinical. The remaining time is often divided between clinical service, teaching, and administrative activities.

Thus, most MD-PhD graduates pursue a career where most of their time is spent on research. This research typically is conducted at academic medical centers, research institutions like NIH, or in the pharmaceutical/biotech industry. With career advancement, many MD-PhD graduates ascend to significant leadership roles in academic medical centers, or industry, government and private organizations, reflecting their broad experience in health care and research.

Training Path for the MD-PhD Graduate

The career of each MD-PhD graduate is uniquely based upon research and clinical interests, but follows the general path:

• MD-PhD training: 7-8 years (See  Education and Training  for more information).
• Specialty and subspecialty clinical and research training (residency/fellowship): 3-7 Years.

Residency and Fellowship Training

Most MD-PhD graduates pursue residency and fellowship training and find that their MD-PhD training makes them particularly attractive to residency programs at top academic institutions. In the past, MD-PhD graduates traditionally entered residency programs in medicine, pediatrics, or pathology. However, the clinical specialty choices of current graduates are more diverse, with many graduates pursuing residency training in neurology, psychiatry, radiology, radiation oncology, and even surgery and surgical specialties.

Research Residency Programs

It is important to note that there are a growing number of "research residency programs" that have been specially developed to foster the career development of physician-scientists.

After completing their specialty clinical training (e.g., in medicine or pediatrics), most physician-scientists pursue subspecialty clinical training (e.g., cardiology or hematology-oncology) and postdoctoral research that typically combines protected research time with intensive clinical training. A number of residency programs around the country offer highly structured programs in which research is fully integrated into the clinical training.

These programs differ in their overall structure, but all offer the following:

• Shortened residency (specialty) training; in general, the integrated programs allow trainees to shorten their residency by one year, depending on the field of specialty.
• Integrated research and clinical training; programs usually offer mentoring for trainees to choose a lab early in their training process, so they can embark on their research right away when they start full time in the lab.
• Guaranteed subspecialty fellowship position in the trainee's desired field; this is not offered at all institutions.
• Special financial support; a few combined programs also offer support both towards salary and research.

Time Commitment

The time commitment required to complete the dual degree and subsequent specialty training can be substantial. Thus, you should thoroughly explore whether combining biomedical research and clinical practice is the right path for you. Despite the time commitment, it is important to recognize that professional progress following MD-PhD training can be swift, and the years of training truly represent a time of great personal as well as professional growth.

The MD-PhD graduate is unique within medical education, representing about 3 percent of the entire graduating medical school class in the United States. In 2006, there were over 16,000 MD graduates; about 500 of these earned PhD degrees as well.

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Emily battled viral encephalitis for years during college, and now as a MD/PhD student, she reminds premeds that it's okay to ask for help.

Cesar couldn't apply to medical school when he first graduated from college due to his undocumented status. Now he's in a MD-PhD program and hopes to practice in the Southwest where there's a high need for Spanish-speaking physicians.